The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats
| Autor: | Junyi Fang, Yan Wang, Chunhong Wang, Shaoxin Huang, Guangqin Fan, L.B. Chen |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Randomization NF-E2-Related Factor 2 Health Toxicology and Mutagenesis Chromosomal translocation Biology Toxicology environment and public health Rats Sprague-Dawley chemistry.chemical_compound Pregnancy Internal medicine Testis medicine Animals Weaning RNA Messenger Maternal-Fetal Exchange Glutathione Transferase Pharmacology Glutathione Disulfide General Medicine Glutathione respiratory system medicine.disease Rats Endocrinology Lead chemistry Lead acetate Immunology Gestation Immunohistochemistry Environmental Pollutants Female Multidrug Resistance-Associated Proteins |
| Zdroj: | Environmental Toxicology and Pharmacology. 35:109-116 |
| ISSN: | 1382-6689 |
| Popis: | Lead is linked to many reproductive problems. This study was to explore the chronic effects of low lead level on expressions of Nrf2 and Mrp1 in rats' testes. Maternal SD rats were administered lead acetate from 10 days before gestation to weaning at three doses respectively after randomization. From each group, 15 male offsprings were then chosen and administrated lead acetate from weaning to six months old at the doses of 0, 0.3 and 0.9g/L respectively. The dose administrations were through drinking water freely. The methods of RT-PCR, Western blotting and immunohistochemistry were used for Mrp1 and Nrf2 of the testes. Compared with control group, significant increases were observed in the expressions of Mrp1 and Nrf2 in two lead groups (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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