Antibodies to the thyroid gland and to the thyrotrophin receptor in African and Indian thyrotoxic patients
| Autor: | Rajput Mc, Joubert Sm, R. K. Desai, M. A K Omar, Jialal I |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases medicine.medical_treatment Graves' disease Thyroid Gland India Disease Thyroglobulin Antibodies Internal medicine medicine Humans Receptor biology business.industry Thyroid Receptors Thyrotropin General Medicine medicine.disease Graves Disease Anti-thyroid autoantibodies Thyrotoxicosis medicine.anatomical_structure Endocrinology Africa biology.protein Lower prevalence Antibody business Research Article Goiter Nodular |
| Zdroj: | Postgraduate Medical Journal. 62:837-839 |
| ISSN: | 1469-0756 0032-5473 |
| DOI: | 10.1136/pgmj.62.731.837 |
| Popis: | Summary Sixty two thyrotoxic patients, 34 African and 28 Indian, were studied in order to assess the prevalence of thyroid antibodies and TSH binding inhibitory activity (TBI): 45 had Graves' disease and 17 had toxic nodular goitres. Microsomal and thyroglobulin antibodies were positive more often in Indian than in African patients with Graves' disease (microsomal 52% vs 37.4%, P < 0.05; thyroglobulin 38.1% vs 4.2%, P < 0.001). Patients with toxic nodular goitres had a lower prevalence of positive microsomal antibodies (P < 0.01), but not of thyroglobulin antibodies (P = 0.1) when compared with patients with Graves' disease. TBI activity measured by a radioreceptor assay was positive in 43 of the 45 (95%) patients with Graves' disease and only 1 of the 17 patients (5.9%) with toxic nodular goitre. It thus appears that TBI activity is a sensitive marker in the diagnosis of Graves' disease and that there is a lower prevalence of thyroglobulin and microsomal antibodies in African patients compared with Indian patients. |
| Databáze: | OpenAIRE |
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