Pegylated interferon alfa-2b pen device and ribavirin treatment for patients with chronic hepatitis C: an evaluation of patient satisfaction
| Autor: | Epameinondas V. Tsianos, Paraskevi Aggelopoulou-Tiga, Spilios Manolakopoulos, Vassilios Delis, Grigoris Giannoulis, Konstantinos Mimidis, Helen Diamanti, Harry Bassaris, Christos Papaioannou, Georgios Tzelas, Jannis Kountouras, I. Ketikoglou, Konstantinos Kaligeros, Dimitrios Dimitroulopoulos, Panagiota Ioannidou, Antonios Perperas, Maria Dimopoulou, Konstantinos Thomopoulos, Sotirios Koutsounas, Maria Kardasi, Antonios Nikolaou, Andreas Protopapas, Stylianos Karatapanis, Elias A. Kouroumalis |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Alpha interferon Interferon alpha-2 Antiviral Agents Injections Polyethylene Glycols chemistry.chemical_compound Patient satisfaction Patient Education as Topic Pegylated interferon Internal medicine Surveys and Questionnaires Ribavirin Medicine Humans Adverse effect Interferon alfa Hepatology business.industry Gastroenterology Interferon-alpha Odds ratio Hepatitis C Equipment Design Hepatitis C Chronic Middle Aged medicine.disease Recombinant Proteins Surgery Logistic Models chemistry Patient Satisfaction Drug Therapy Combination Female business medicine.drug |
| Zdroj: | European journal of gastroenterologyhepatology. 22(9) |
| ISSN: | 1473-5687 |
| Popis: | Objective The aim of this study was to evaluate the satisfaction of patients with chronic hepatitis C who used the pegylated interferon α-2b pen device. Methods Patients from multiple centers in Greece were recruited to participate in this noninterventional, observational study. Patients received pen device training for at least 6 weeks before treatment and used questionnaires to provide feedback (rating scale: 1-4, negative; 5-7, positive) on training, medication preparation and injection, and appreciation of the device. Results were analyzed with standard statistical analysis and multivariate logistic regression. Results In total, 507 patients (mean age, 43.5 years), 77.4% of whom were treatment naive, participated in the study. Overall, 84.2% of patients rated training positively, 67.4% of patients rated medication preparation positively, and 88.3% of patients rated medication injection positively. Appreciation of the pen device treatment method was rated positively by 82.2% of patients. Intravenous drug users were more likely to rate medication injection positively (P=0.028 4 ) and to appreciate this method of drug delivery (P=0.0328) than other patients. Patients with lower levels of education were less likely to rate training positively (P=0. 0202 ) and showed less appreciation for this route of drug delivery (P=0.0341) than other patients. Treatment-naive patients were more likely to provide positive responses about the overall procedure than were treatment-experienced patients (odds ratio: 1.932; P=0 . 0 32) . Adverse events were reported by 6.4% (29 of 453) of patients. Conclusion Patients were satisfied with the pegylated interferon α-2b pen device; therefore, good treatment adherence is expected with its use. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|