Elevated plasma fibrinogen levels in multiple sclerosis patients during relapse
| Autor: | Alberto Lozano Ros, María Luisa Martínez Ginés, Milagros Hidalgo de la Cruz, Clara Dionisia de Andrés Frutos, Saskia Prasca Tapia, Jahir Andrés Miranda Acuña |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Fibrinogen Sensitivity and Specificity Gastroenterology Lesion 03 medical and health sciences Multiple Sclerosis Relapsing-Remitting 0302 clinical medicine Recurrence Internal medicine medicine Humans Clinically isolated syndrome medicine.diagnostic_test business.industry Multiple sclerosis Brain Magnetic resonance imaging General Medicine Multiple Sclerosis Chronic Progressive medicine.disease Spinal cord Magnetic Resonance Imaging Thrombosis 030104 developmental biology medicine.anatomical_structure Spinal Cord Neurology Coagulation Female Neurology (clinical) medicine.symptom business Biomarkers 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Multiple Sclerosis and Related Disorders. 18:157-160 |
| ISSN: | 2211-0348 |
| Popis: | Fibrinogen is a protein that plays a key role in blood coagulation and thrombosis and it is involved in several inflammatory processes; in multiple sclerosis (MS) may be related with blood-brain barrier (BBB) disruption. We analysed the relationship between plasma fibrinogen levels and the presence of active lesions on magnetic resonance imaging (MRI) during relapses of multiple sclerosis (MS) and clinically isolated syndrome (CIS) patients.We collected data of patients admitted to a tertiary-care hospital with relapse of MS and CIS from 2008 to 2013 and we analysed the relation between plasma fibrinogen levels (normal: 200mg/dl-417mg/dl) and the presence of active lesions on brain or spinal MRI.A total of 58 patients were included, 45 (77%) CIS patients, 12 (21%) relapsing-remitting MS (RR-MS) and 1 (2%) active progressive MS (P-MS). 17 patients had high plasma fibrinogen levels (417mg/dl). Among total of patients with elevated plasma fibrinogen, 15 (88%) had active lesions on MRI and only 2 (12%) did not have active lesion on MRI (p = 0,013) with a specificity of 95%. All patients with fibrinogen417mg/dl were CIS (p =0.05).We observed that high plasma fibrinogen levels had a high specificity high specificity, but low sensitivity (only 40%) for detection of active lesions on MRI during relapses of MS. These findings support the hypothesis that fibrinogen could play an important role on the development of MS lesions, however, additional studies are needed to confirm these results. |
| Databáze: | OpenAIRE |
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