Acquired equine polyneuropathy of Nordic horses:A conspicuous inclusion body schwannopathy
| Autor: | S. Hanche-Olsen, Kaspar Matiasek, Marco Rosati, Jessica Molin, G. Gröndahl, Caroline Hahn, K. Hultin Jäderlund |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Pathology medicine.medical_specialty 040301 veterinary sciences Nerve pathology Knuckling Schwann cell 0403 veterinary science Polyneuropathies 03 medical and health sciences 0302 clinical medicine Animals Medicine Horses Genetics (clinical) Inflammatory Sweden Inclusion body Nerve fibre teasing Norway business.industry Muscles Schwannopathy 04 agricultural and veterinary sciences medicine.disease medicine.anatomical_structure Neurology Pediatrics Perinatology and Child Health Etiology Female Horse Diseases Schwann Cells Neurology (clinical) Demyelination business Polyneuropathy 030217 neurology & neurosurgery |
| Zdroj: | Hanche-Olsen, S, Matiasek, K, Molín, J, Rosati, M, Hahn, C, Hultin Jäderlund, K & Gröndahl, G 2017, ' Acquired equine polyneuropathy of Nordic horses : A conspicuous inclusion body schwannopathy ', Neuromuscular Disorders, vol. 27, no. 10, pp. 931-941 . https://doi.org/10.1016/j.nmd.2017.06.005 Neuromuscular Disorders |
| Popis: | Acquired equine polyneuropathy (AEP), formerly also known as Scandinavian knuckling syndrome, is one of the most prevalent polyneuropathies in equids in Norway and Sweden, with more than 400 cases registered since first observations in 1995. Despite geographical clustering and an association to forage feeding, its aetiology remains unknown. Clinically AEP is characterized by knuckling due to dysfunction of metatarsophalangeal extensor muscles. This neuropathological study aimed to gain further insights in the pathobiology of AEP and its underlying aetiopathogenesis. We thereby confirmed that all affected horses suffered from similar large fibre neuropathy, exhibiting conspicuous Schwann cell inclusions in most samples, suggestive of a primary disruption of Schwann cell metabolism leading to inclusion body schwannopathy with secondary inflammatory changes. The degree of nerve pathology was not predictive of clinical outcome. |
| Databáze: | OpenAIRE |
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