Diversity of group A rotavirus genes detected in the Triângulo Mineiro region, Minas Gerais, Brazil
| Autor: | George Silva, André L.S Domingues, Felipe Gomes Naveca, Ana Carolina Bernardes Dulgheroff, Adriana Gonçalves de Oliveira |
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| Rok vydání: | 2016 |
| Předmět: |
Rotavirus
0301 basic medicine Lineage (genetic) Genes Viral Genotype viruses 030106 microbiology Reassortment lcsh:QR1-502 Context (language use) Biology medicine.disease_cause Microbiology Genome Rotavirus Infections lcsh:Microbiology Feces Infantile diarrhea 03 medical and health sciences Genetic variation medicine Humans Gene Phylogeny Genetics Biodiversity Genetics and Molecular Microbiology Virology Gastroenteritis 030104 developmental biology Brazil |
| Zdroj: | Brazilian Journal of Microbiology v.47 n.3 2016 Brazilian Journal of Microbiology Sociedade Brasileira de Microbiologia (SBM) instacron:SBM Brazilian Journal of Microbiology, Vol 47, Iss 3, Pp 731-740 Brazilian Journal of Microbiology, Volume: 47, Issue: 3, Pages: 731-740, Published: SEP 2016 |
| ISSN: | 1517-8382 |
| DOI: | 10.1016/j.bjm.2016.04.012 |
| Popis: | Group A rotaviruses are the main causative agent of infantile gastroenteritis. The segmented nature of the viral genome allows reassortment of genome segments, which can generate genetic variants. In this study, we characterized the diversity of the VP7, VP4 (VP8*), VP6, NSP4, and NSP5 genes of the rotaviruses that circulated from 2005 to 2011 in the Triângulo Mineiro (TM) region of Brazil. Samples with genotypes G2 (sublineages IVa-1 and IVa-3), G1 (sublineage I-A), G9 (lineage III), G12 (lineages II and III), G8 (lineage II), G3 (lineage III), P[4] (sublineages IVa and IVb), P[8] (sublineages P[8]-3.6, P[8]-3.3, and P[8]-3.1), I2 (lineage VII), E2 (lineages VI, XII, and X), and H2 (lineage III) were identified. The associations found in the samples were G1, G9, or G12 with P[8]-I1-E1-H1; G2 or G8 with P[4]-I2-E2-H2; G12 with I3-E3-H6; and G3 with P[4]-I2-E3-H3 (previously unreported combination). Reassortment events in G2P[4] strains and an apparent pattern of temporal segregation within the lineages were observed. Five TM samples contained genes that exhibited high nucleotide and amino acid identities with strains of animal origin. The present study includes a period of pre- and post-introduction of rotavirus vaccination in all Brazilian territories, thereby serving as a basis for monitoring changes in the genetic constitution of rotaviruses. The results also contribute to the understanding of the diversity and evolution of rotaviruses in a global context. |
| Databáze: | OpenAIRE |
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