Risk Factors for Ipsilateral Breast Tumor Recurrence in Triple-Negative or HER2-Positive Breast Cancer Patients Who Achieve a Pathologic Complete Response After Neoadjuvant Chemotherapy

Autor: Naoki Hayashi, Ryu Tokui, Koichiro Tsugawa, Yasuyuki Kojima, Mizuho Tazo, Tomoko Ogawa, Atsushi Yoshida, Seigo Nakamura, Naoko Matsuda, Makoto Ishitobi, Sayuka Nakayama, Takahiro Nakayama, Hideko Yamauchi, Takashi Kuwayama
Rok vydání: 2020
Předmět:
Zdroj: Annals of Surgical Oncology. 28:2545-2552
ISSN: 1534-4681
1068-9265
DOI: 10.1245/s10434-020-09176-0
Popis: Attention has been focused on attempts to eliminate breast surgery for breast cancer patients who achieve a pathologic complete response after neoadjuvant chemotherapy (NAC). However, there are few data on ipsilateral breast tumor recurrence (IBTR) among patients with triple-negative or epidermal growth factor receptor 2-positive (HER2+) tumors who achieve a pathologic complete response after NAC and breast-conserving treatment. Using a multi-institutional retrospective database, this study evaluated the risk factors for IBTR among patients with newly diagnosed stages 1 to 3 breast cancer involving triple-negative or HER2+ tumors who achieved ypT0 after NAC and breast-conserving treatment. During a median follow-up period of 4.8 years (range, 0.1–15.5 years), the 5-year IBTR-free survival rate was 95.5%. The breast cancer subtype was not associated with IBTR-free survival. Patients younger than 40 years at diagnosis had significantly worse IBTR-free survival than those who were 40 years of age or older (5-year IBTR-free survival, 87.7 vs 96.9%; p = 0.002). This retrospective study demonstrated that age at diagnosis was independently associated with IBTR-free survival. Special caution is needed when clinical trials analyzing omission of breast surgery after NAC are enrolling younger patients (UMIN-CTR No. UMIN000037067).
Databáze: OpenAIRE
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