Supplementary Methods from Phase I, Dose-Escalation, Two-Part Trial of the PARP Inhibitor Talazoparib in Patients with Advanced Germline BRCA1/2 Mutations and Selected Sporadic Cancers

Autor: Zev A. Wainberg, Lauren Averett Byers, Nicola J. Curtin, Miranda Patterson, Ashleigh Herriott, Joshua W. Henshaw, David C. Smith, John Heymach, Jasgit Sachdev, Stan Kaye, Saeed Rafii, John Glaspy, Rashmi Chugh, Lida Mina, Ramesh K. Ramanathan, Johann de Bono
Rok vydání: 2023
Popis: Supplementary Methods includes additional details on these topics: tumors eligible for dose escalation phase; tumors eligible for dose expansion phase; patients enrolled using a local laboratory; study design and participants; additional inclusion criteria; full list of exclusion criteria; study treatment; study procedures; pharmacodynamic (PD) analysis; inhibition of PBMC PARP activity.
Databáze: OpenAIRE