Neurological deficit is predicted by S100B in children after cardiac surgery
| Autor: | R. Hemi, O. Bar-Yosef, A. Vardi, T. Tirosh, D. Greidinger, M. Iskilova |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Neurology Clinical Biochemistry S100 Calcium Binding Protein beta Subunit 030204 cardiovascular system & hematology Biochemistry 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests medicine Pediatric stroke Humans Cardiac Surgical Procedures Neurological deficit Retrospective Studies Pediatric intensive care unit business.industry Biochemistry (medical) Outcome measures Infant General Medicine medicine.disease Predictive value Cardiac surgery Stroke Anesthesia Brain Injuries Child Preschool Biomarker (medicine) Female business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 481 |
| ISSN: | 1873-3492 |
| Popis: | Introduction Children undergoing cardiac surgery may suffer from brain injuries after surgery and develop neurological deficit. Early diagnosis of brain injury after surgery would enable early therapeutic interventions. The aim of the study is to test whether S100B can serve as a biomarker for brain injury after cardiac surgery. Methods Seventy-five patients were enrolled in the study. Serum S100B was collected at the beginning of the surgery, and 6, 12, 24 h after surgery. S100B z-scores were calculated based on norms for age. Neurological evolutions were done before surgery and at discharge by the Pediatric Stroke Outcome Measure (PSOM). New neurological deficit (NND) was defined as a 1 point increase on the PSOM scale. Results Twenty patients had an NND after cardiac surgery. Medical background was similar between the groups with and without NND. S100B z-scores were significantly higher in the NND group at all time points after surgery. Using a cut-off of 3 z-score at 6 h after surgery, the positive predictive value was 79% and the negative predictive value was 90%. Conclusions S100B is a potent early biomarker for brain injury after cardiac surgery. Hopefully, S100B could be used to prevent progression of brain injuries after cardiac surgery. |
| Databáze: | OpenAIRE |
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