Interaction of some traditional plant extracts with uterine oestrogen or progestin receptors

Autor: Marie-Lise Thieulant, Tanon Benie
Přispěvatelé: Interactions Cellulaires et Moléculaires, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-IFR98-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-IFR98-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2003
Předmět:
medicine.medical_specialty
Steroid hormone receptor
Cola nitida
ved/biology.organism_classification_rank.species
Estrogen receptor
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
Pharmacognosy
01 natural sciences
progesterone receptor
03 medical and health sciences
Inhibitory Concentration 50
Internal medicine
Progesterone receptor
medicine
Animals
Receptor
skin and connective tissue diseases
Malvaceae
Medicine
African Traditional
030304 developmental biology
Pharmacology
0303 health sciences
Plants
Medicinal
Dose-Response Relationship
Drug
Estradiol
ved/biology
uterine horns
Plant Extracts
Barringtonia
Uterus
Estrogen Antagonists
Biological activity
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular biology
[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology
Fabaceae
0104 chemical sciences
oestrogen receptor
010404 medicinal & biomolecular chemistry
Endocrinology
Mechanism of action
Receptors
Estrogen
Plant Bark
Cattle
Female
medicine.symptom
Receptors
Progesterone
Phytotherapy
Zdroj: Phytotherapy Research
Phytotherapy Research, Wiley, 2003, 17 (7), pp.756-760. ⟨10.1002/ptr.1208⟩
Phytotherapy Research, 2003, 17 (7), pp.756-760. ⟨10.1002/ptr.1208⟩
ISSN: 0951-418X
1099-1573
DOI: 10.1002/ptr.1208⟩
Popis: International audience; Previous work has demonstrated that stem bark extracts of Combretodendron macrocarpum (Barringtoniaceae), Cola nitida (Sterculiaceae), Afrormosia laxiflora and Pterocarpus erinaceus (Fabaceae) blocked the oestrus cycle of female rats through antigonadotropic activity. Moreover, a study of the plant substances responsible for these effects revealed the presence of phyto-anti-oestrogens in these plant extracts. In order to explain the mechanism by which these substances exert their antifertility actions, the interaction of the plant extract with oestrogen and progesterone receptors was studied. All crude extracts exerted inhibition of ((3)H)-oestradiol or ((3)H)-Organon binding to their respective receptors but their relative affinities were much lower than those of oestradiol or progesterone. Respective efficiencies of plant extracts in competing for the oestrogen receptor were as follows: A. laxiflora > P. erinaceus > C. macrocarpum > C. nitida. The efficiency order of competition for the progestin receptor was different to that of oestrogen. The most potent competitor was C. macrocarpum extract, followed by P. erinaceus, C. nitida and A. laxiflora. Moreover, the interaction between oestradiol and plant extracts with the oestrogen receptor was determined to be competitive only for C. macrocarpum and A. laxiflora, whereas all compounds produced a competitive inhibition on the progestin receptor binding. These results suggest that the plant extract binding site was the same site as for the steroid. These results suggest also that crude plant extracts may interfere with natural oestrogen and/or progestagen in vivo by binding to steroid receptors
Databáze: OpenAIRE
Externí odkaz: