Cardiovascular magnetic resonance evidence of myocardial fibrosis and its clinical significance in adolescent and adult patients with Ebstein’s anomaly
| Autor: | Yuchi Han, Qi An, Ke Wan, Wei Cheng, Hong Liu, Yucheng Chen, Dan Yang, Yiu-Cho Chung, Andreas Greiser, Jiayu Sun, Xiao Li, Yong Luo, Tianjing Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Gadolinium DTPA
Male lcsh:Diseases of the circulatory (Cardiovascular) system Heart disease Contrast Media 030204 cardiovascular system & hematology Severity of Illness Index Late gadolinium enhancement Ventricular Function Left 030218 nuclear medicine & medical imaging Ventricular Dysfunction Left 0302 clinical medicine Risk Factors Myocardial fibrosis Prevalence Registries Child Ejection fraction Ventricular Remodeling Radiological and Ultrasound Technology Left ventricular function Age Factors Prognosis medicine.anatomical_structure Disease Progression Cardiology Female Cardiology and Cardiovascular Medicine Extracellular volume Adult China medicine.medical_specialty Adolescent Ebstein’s anomaly Magnetic Resonance Imaging Cine Young Adult 03 medical and health sciences Predictive Value of Tests Ebstein's anomaly Internal medicine medicine Humans Radiology Nuclear Medicine and imaging cardiovascular diseases Ventricular remodeling Endocardium Angiology Cardiovascular magnetic resonance imaging business.industry Research Myocardium Stroke Volume medicine.disease Fibrosis Ebstein Anomaly Cross-Sectional Studies Ventricle lcsh:RC666-701 Case-Control Studies business |
| Zdroj: | Journal of Cardiovascular Magnetic Resonance, Vol 20, Iss 1, Pp 1-10 (2018) Journal of Cardiovascular Magnetic Resonance |
| Popis: | Background Myocardial fibrosis is a common pathophysiological process that is related to ventricular remodeling in congenital heart disease. However, the presence, characteristics, and clinical significance of myocardial fibrosis in Ebstein’s anomaly have not been fully investigated. This study aimed to evaluate myocardial fibrosis using cardiovascular magnetic resonance (CMR) late gadolinium enhancement (LGE) and T1 mapping techniques, and to explore the significance of myocardial fibrosis in adolescent and adult patients with Ebstein’s anomaly. Methods Forty-four consecutive patients with unrepaired Ebstein’s anomaly (34.0 ± 16.2 years; 18 males), and an equal number of age- and gender-matched controls, were included. A comprehensive CMR protocol consisted of cine, LGE, and T1 mapping by modified Look-Locker inversion recovery (MOLLI) sequences were performed. Ventricular functional parameters, native T1, extracellular volume (ECV), and LGE were analyzed. Associations between myocardial fibrosis and disease severity, ventricular function, and NYHA classification were analyzed. Results LGE was found in 10 (22.7%) patients. Typical LGE in Ebstein’s anomaly was located in the endocardium of the septum within the right ventricle (RV). The LV ECV of Ebstein’s anomaly were significantly higher than those of the controls (30.0 ± 3.8% vs. 25.3 ± 2.3%, P |
| Databáze: | OpenAIRE |
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