Outcomes of primary membranous nephropathy based on serum anti-phospholipase A2 receptor antibodies and glomerular phospholipase A2 receptor antigen status: a retrospective cohort study

Autor: Xiaofan Tan, Linda Zhan, Peihong Yin, Xiaohong Chen, Wenyi Liang, Qing Ye, Yuanhao Liu, Jian Lin, Zhibin Xie, Junxian Wang, Hongyun Jian, Yingqin He, Fengxian Huang
Rok vydání: 2020
Předmět:
Adult
Male
viruses
Kidney Glomerulus
030232 urology & nephrology
030204 cardiovascular system & hematology
lcsh:RC870-923
Critical Care and Intensive Care Medicine
Glomerulonephritis
Membranous
03 medical and health sciences
remission
0302 clinical medicine
Membranous nephropathy
Antigen
medicine
Humans
Receptor
Aged
Autoantibodies
Proportional Hazards Models
Retrospective Studies
Outcome
phospholipase A2 receptor
biology
business.industry
Receptors
Phospholipase A2
Remission Induction
Retrospective cohort study
General Medicine
Middle Aged
lcsh:Diseases of the genitourinary system. Urology
Prognosis
medicine.disease
Nephrology
Multivariate Analysis
Immunology
Clinical Study
biology.protein
Female
rimary membranous nephropathy
Antibody
business
Biomarkers
Phospholipase A2 receptor
Research Article
Zdroj: Renal Failure
article-version (VoR) Version of Record
Renal Failure, Vol 42, Iss 1, Pp 675-683 (2020)
ISSN: 1525-6049
0886-022X
DOI: 10.1080/0886022x.2020.1792315
Popis: Introduction Primary membranous nephropathy (PMN) is associated with the anti-phospholipase A2 receptor (anti-PLA2R) antibody in 70% of cases. Some anti-PLA2R-negative patients have the PLA2R antigen in renal tissue. This study examined the prognosis of patients with PMN according to their serum anti-PLA2R antibody (SAb) and glomerular PLA2R antigen (GAg) status. Methods Patients diagnosed with PMN were included retrospectively. Patients were grouped according to their PLA2R status into the SAb−/GAg−, SAb−/GAg+, and SAb+/GAg + groups. Baseline data, renal biopsy results, treatment, and clinical data were compared among the groups. Cox univariable and multivariable analyses examined the factors related to complete remission (CR). Results A total of 114 patients were enrolled; 10 (9%) in the SAb−/GAg−, 23 (20%) in the SAb−/GAg+, and 81 (71%) in the SAb+/GAg+ groups. Cumulative CR rate showed a significant difference between the SAb−/GAg − and SAb+/GAg+ groups (log-rank p = 0.003). The multivariable Cox proportional hazard analysis showed that age (HR = 0.968; 95%CI = 0.946–0.990; p = 0.005), SAb+/GAg+ versus SAb−/GAg− (HR = 0.387; 95%CI = 0.190–0.788; p = 0.009), SAb−/GAg+ versus SAb−/GAg− (HR = 0.398; 95%CI = 0.169, 0.939; p = 0.035), total renal chronicity score ≥2 (HR = 0.461, 95%CI: 0.277–0.766, p = 0.003), and IgA deposition (HR = 2.596; 95%CI = 1.227–5.492; p = 0.013) were all independently related (p
Databáze: OpenAIRE
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