When the ostrich-algorithm fails: Blanking method affects spike train statistics
| Autor: | Kevin Joseph, Soheil Mottaghi, Olaf Christ, Thomas J. Feuerstein, Ulrich G. Hofmann |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Computer science Acoustics Spike train Ostrich algorithm stimulation Signal lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine spike detection Premovement neuronal activity lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Original Research Electronic circuit Ground General Neuroscience blanking circuit electrophysiology Electrophysiology 030104 developmental biology stimulation artifact Spike (software development) 030217 neurology & neurosurgery Blanking Neuroscience |
| Zdroj: | Frontiers in Neuroscience, Vol 12 (2018) Frontiers in Neuroscience |
| DOI: | 10.1101/166611 |
| Popis: | Modern electroceuticals are bound to employ the usage of electrical high frequency (130–180 Hz) stimulation carried out under closed loop control, most prominent in the case of movement disorders. However, particular challenges are faced when electrical recordings of neuronal tissue are carried out during high frequency electrical stimulation, both in-vivo and in-vitro. This stimulation produces undesired artifacts and can render the recorded signal only partially useful. The extent of these artifacts is often reduced by temporarily grounding the recording input during stimulation pulses. In the following study, we quantify the effects of this method, “blanking,” on the spike count and spike train statistics. Starting from a theoretical standpoint, we calculate a loss in the absolute number of action potentials, depending on: width of the blanking window, frequency of stimulation, and intrinsic neuronal activity. These calculations were then corroborated by actual high signal to noise ratio (SNR) single cell recordings. We state that, for clinically relevant frequencies of 130 Hz (used for movement disorders) and realistic blanking windows of 2 ms, up to 27% of actual existing spikes are lost. We strongly advice cautioned use of the blanking method when spike rate quantification is attempted. Impact statement Blanking (artifact removal by temporarily grounding input), depending on recording parameters, can lead to significant spike loss. Very careful use of blanking circuits is advised. |
| Databáze: | OpenAIRE |
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