Confounders in Identification and Analysis of Inflammatory Biomarkers in Cardiovascular Diseases
| Autor: | Neng Fisheri Kurniati, Gayuk Kalih Prasesti, Qurrat Ul Ain, Triwedya Indra Dewi, Mehak Sarfraz |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
epidemiological factors
Interleukin-1beta Inflammation chemokines Disease Review Bioinformatics Systemic inflammation Biochemistry Microbiology Receptors Tumor Necrosis Factor pro-inflammatory biomarkers Proinflammatory cytokine medicine Humans Immunologic Factors confounding factors Molecular Biology Epidemiological Factors business.industry Interleukin-6 Tumor Necrosis Factor-alpha Acute-phase protein demographic factors cytokines QR1-502 pre-analytical factors C-Reactive Protein Cardiovascular Diseases inflammation acute-phase proteins Sample collection medicine.symptom business Body mass index Biomarkers |
| Zdroj: | Biomolecules, Vol 11, Iss 1464, p 1464 (2021) Biomolecules |
| Popis: | Proinflammatory biomarkers have been increasingly used in epidemiologic and intervention studies over the past decades to evaluate and identify an association of systemic inflammation with cardiovascular diseases. Although there is a strong correlation between the elevated level of inflammatory biomarkers and the pathology of various cardiovascular diseases, the mechanisms of the underlying cause are unclear. Identification of pro-inflammatory biomarkers such as cytokines, chemokines, acute phase proteins, and other soluble immune factors can help in the early diagnosis of disease. The presence of certain confounding factors such as variations in age, sex, socio-economic status, body mass index, medication and other substance use, and medical illness, as well as inconsistencies in methodological practices such as sample collection, assaying, and data cleaning and transformation, may contribute to variations in results. The purpose of the review is to identify and summarize the effect of demographic factors, epidemiological factors, medication use, and analytical and pre-analytical factors with a panel of inflammatory biomarkers CRP, IL-1b, IL-6, TNFa, and the soluble TNF receptors on the concentration of these inflammatory biomarkers in serum. |
| Databáze: | OpenAIRE |
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