Can Solid-Organ–Transplanted Patients Perform a Cycling Marathon? Trends in Kidney Function Parameters in Comparison With Healthy Subjects
| Autor: | M. Tonioli, W. Balzi, Valentina Totti, Manuela Trerotola, D. Storani, G. Mosconi, A.N. Costa, Maria Cappuccilli, M.L. Angelini, G.S. Roi |
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| Přispěvatelé: | Mosconi, G, Angelini, Ml, Balzi, W, Totti, V, Roi, G, Cappuccilli, M, Tonioli, M, Storani, D, Trerotola, M, Costa, An. |
| Rok vydání: | 2016 |
| Předmět: |
Male
Urine 030204 cardiovascular system & hematology 030230 surgery Kidney Kidney Function Tests chemistry.chemical_compound 0302 clinical medicine Urea Specific Gravity Sport education.field_of_study Proteinuria Middle Aged Healthy Volunteers medicine.anatomical_structure Creatinine Female medicine.symptom Glomerular Filtration Rate Adult medicine.medical_specialty Population Urology Renal function 03 medical and health sciences Kidney function medicine Albuminuria Humans education Exercise Transplantation business.industry Urine specific gravity Organ solid transplant medicine.disease Kidney Transplantation Transplant Recipients Bicycling Liver Transplantation Uric Acid chemistry Case-Control Studies Physical therapy Heart Transplantation Surgery Microalbuminuria business |
| Zdroj: | Transplantation Proceedings. 48:415-419 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2015.12.042 |
| Popis: | Background Few solid-organ–transplanted patients (TP) perform regular sport activity. Poor data are available on the safety of intense and prolonged physical exercise on this population. The aim of the study was to evaluate kidney function parameters in a group of TP in comparison with healthy volunteers (HV) involved in a long-distance road cycling race: length 130 km and total uphill gradient, 1871 m. Methods Nineteen TP were recruited: 10 renal, 8 liver, and 1 heart and compared with 35 HV. Renal function parameters, namely, creatinine, estimated glomerular filtration rate (eGFR), urea, uric acid, urine specific gravity, microalbuminuria, and proteinuria were collected and their values were compared the day before the race (T1), immediately after crossing the finish line (T2), and 18 to 24 hours after the competition (T3). Results No adverse events were recorded. At baseline, TP showed lower values of eGFR (69 ± 22 versus 87 ± 13 mL/min/1.73 m2), lower urine specific gravity (1015 ± 4 versus 1019 ± 6), and higher microalbuminuria (56 ± 74 versus 8 ± 15) and proteinuria values (166 ± 99 versus 74 ± 44) (in mg/L). At T2 in both groups, renal function parameters showed the same trends: decline of eGFR (54 ± 19 versus 69 ± 15 mL/min/1.73 m2) and rise in protein excretion. At T3, functional parameters returned to baseline, except for urine specific gravity values remaining stable in TP (1018 ± 6) and growing higher in HV (1028 ± 4). Conclusions Selected and well-trained organ-transplanted patients can perform an intensive exercise, displaying temporary modifications on kidney function parameters comparable to healthy subjects, despite differences related to baseline clinical conditions and pharmacological therapies. |
| Databáze: | OpenAIRE |
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