Telomere targeting approaches in cancer: beyond length maintenance
| Autor: | Eleonora Vertecchi, Erica Salvati, Angela Rizzo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Organic Chemistry
shelterins Telomere Homeostasis G-quadruplex ligands cancer telomeres DNA General Medicine Telomere Catalysis Computer Science Applications Inorganic Chemistry Neoplasms Humans Physical and Theoretical Chemistry Telomerase Molecular Biology Cellular Senescence Spectroscopy DNA Damage |
| Popis: | Telomeres are crucial structures that preserve genome stability. Their progressive erosion over numerous DNA duplications determines the senescence of cells and organisms. As telomere length homeostasis is critical for cancer development, nowadays, telomere maintenance mechanisms are established targets in cancer treatment. Besides telomere elongation, telomere dysfunction impinges on intracellular signaling pathways, in particular DNA damage signaling and repair, affecting cancer cell survival and proliferation. This review summarizes and discusses recent findings in anticancer drug development targeting different “telosome” components. |
| Databáze: | OpenAIRE |
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