Pregnancy in women with cystinosis
| Autor: | Ellen Knox, Graham Lipkin, Jemma Proudfoot-Jones, Hannah Blakey |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
end-stage renal disease
pregnancy Pediatrics medicine.medical_specialty Early pregnancy factor Disease 030230 surgery 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy cysteamine medicine In patient Kidney transplantation Transplantation 030219 obstetrics & reproductive medicine biology business.industry medicine.disease Optimal management cystinosis chemistry Nephrology Cystinosis biology.protein Cysteamine business chronic kidney disease |
| Zdroj: | Clinical Kidney Journal |
| ISSN: | 2048-8513 2048-8505 |
| Popis: | Cystinosis is a rare autosomal recessive disease causing cystine deposition in all tissues, primarily affecting the kidneys. There are few published reports of pregnancy in women with cystinosis, and little evidence is available regarding optimal management. Kidney transplantation and cystine-depleting therapy have transformed the prognosis of cystinosis, and pregnancy is increasingly considered. The evidence base for cystinosis management in pregnancy, therefore, requires expansion. We report three successful pregnancy outcomes and five early pregnancy losses in two women with cystinosis. The challenges of pregnancy in patients with cystinosis are discussed. Pre-pregnancy planning and antenatal management in a specialist renal obstetric clinic are paramount. |
| Databáze: | OpenAIRE |
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