Lung retention and bioavailability of arsenic after single intratracheal administration of sodium arsenite, sodium arsenate, fly ash and copper smelter dust in the hamster
| Autor: | Robert Lauwerys, J. P. Buchet, Janice W. Yager |
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| Rok vydání: | 1995 |
| Předmět: |
Environmental Engineering
Sodium arsenite Metallurgy chemistry.chemical_element General Medicine respiratory system Particulates respiratory tract diseases Bioavailability Excretion chemistry.chemical_compound chemistry Geochemistry and Petrology Environmental chemistry Fly ash Environmental Chemistry Sodium arsenate Solubility Arsenic General Environmental Science Water Science and Technology |
| Zdroj: | Environmental Geochemistry and Health. 17:182-188 |
| ISSN: | 1573-2983 0269-4042 |
| Popis: | Arsenic is present in airborne particulate material released by coal-fired power plants and non-ferrous metal smelters. We have assessed whether the physico-chemical properties of arsenic in such particles play a role in its lung retention and uptake by the body. Female hamsters were given a single intratracheal instillation of fly ash or copper smelter dust suspensions (at doses of 50 or 100 mu g As kg(-1)) or identical amounts of soluble tri- and pentavalent arsenic, in the presence or absence of an inert dust material (tungsten carbide). The concentration of the element was measured in a 24 hour urine sample collected on the 1st, 2nd and 6th day after treatment and arsenic remaining in lung tissue was determined at the end of the same time periods. Both lung retention and urinary As excretion indicate a prolonged contact of the lung tissue with particulate As in contrast to soluble As salts. In addition to the effect of solubility described here, more research is needed to determine the effect of particle size and lung loading on retention, as well as the potential differences in the lung inflammatory response using arsenic-rich particulates from various sources. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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