Induction of marked hypergammaglobulinemia with xenogeneic tumors in hamsters: immunopathologic studies
| Autor: | Alan Ve Richman, Vittorio Defendi |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adenoma
Male Antibodies Neoplasm Immune Sera Immunology Cell Membrane Transplantation Heterologous Fluorescent Antibody Technique Prostatic Neoplasms Complement System Proteins Blood Protein Electrophoresis Cytotoxicity Tests Immunologic Kidney Antigens Neoplasm Transplantation Immunology Cricetinae Culture Techniques Hypergammaglobulinemia Immunology and Allergy Animals Humans gamma-Globulins Neoplasm Transplantation |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 112(6) |
| ISSN: | 0022-1767 |
| Popis: | Human heteroploid cells derived from a benign prostatic adenoma, MA160, can grow progressively in the subcutaneous tissues of 2-day-old nonimmunosuppressed hamsters. The growth of these xenografts is associated with certain immunopathologic features. These features are: A marked increase in the serum of electrophoretically restricted IgG which parallels tumor growth.The appearance of noncytotoxic antibody against membrane antigens of the transplanted cells which is related to the IgG elevation but which constitutes only a very minor part of this elevation; and the fixation of antibody to the tumor cell membrane in situ.The extensive plasma cell proliferation, and the presence of circulating immune complexes (as indicated by the granular deposition of IgG and complement (C3) in the renal glomeruli).The lack of demonstrable biologic activity of the serum (enhancement or cytotoxicity). This transplantation system has analogies with certain chronic viral infections in animals; and our inability to detect antibody specificity for much of the IgG may be related to the presence of circulating immune complexes. Finally we suggest that this system may provide a model from which to study the evolution and pathogenesis of plasma cell dyscrasias. |
| Databáze: | OpenAIRE |
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