The effect of pores and connections geometries on bone ingrowth into titanium scaffolds: an assessment based on 3D microCT images
| Autor: | Monica Talarico Duailibi, Silvio Eduardo Duailibi, Celso Peres Fernandes, Flávio de Ávila Kfouri, Alexandre Antunes Ribeiro, Iara Frangiotti Mantovani, Anderson Camargo Moreira, Marize Varella de Oliveira |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Materials science X-ray microtomography Biomedical Engineering chemistry.chemical_element Biocompatible Materials Bioengineering Bone tissue Osseointegration Biomaterials Imaging Three-Dimensional medicine Animals Bone regeneration Titanium Tibia Tissue Scaffolds Regeneration (biology) Biomaterial X-Ray Microtomography Fluid transport medicine.anatomical_structure chemistry Rabbits Biomedical engineering |
| Zdroj: | Biomedical Materials. 16:065010 |
| ISSN: | 1748-605X 1748-6041 |
| Popis: | In order to support bone tissue regeneration, porous biomaterial implants (scaffolds) must offer chemical and mechanical properties, besides favorable fluid transport. Titanium implants provide these requirements, and depending on their microstructural parameters, the osteointegration process can be stimulated. The pore structure of scaffolds plays an essential role in this process, guiding fluid transport for neo-bone regeneration. The objective of this work was to analyze geometric and morphologic parameters of the porous microstructure of implants and analyze their influences in the bone regeneration process, and then discuss which parameters are the most fundamental. Bone ingrowths into two different sorts of porous titanium implants were analyzed after 7, 14, 21, 28, and 35 incubation days in experimental animal models. Measurements were accomplished with x-ray microtomography image analysis from rabbit tibiae, applying a pore-network technique. Taking into account the most favorable pore sizes for neo-bone regeneration, a novel approach was employed to assess the influence of the pore structure on this process: the analyses were carried out considering minimum pore and connection sizes. With this technique, pores and connections were analyzed separately and the influence of connectivity was deeply evaluated. This investigation showed a considerable influence of the size of connections on the permeability parameter and consequently on the neo-bone regeneration. The results indicate that the processing of porous scaffolds must be focused on deliver pore connections that stimulate the transport of fluids throughout the implant to be applied as a bone replacer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|