Epigenetic Alterations in Pediatric Sleep Apnea
| Autor: | Matthew W. Kay, Emily Catherine Cheung, Kathryn J Schunke |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Epigenomics
RNA Untranslated QH301-705.5 Review Bioinformatics Catalysis Epigenesis Genetic Inorganic Chemistry Histones Sleep Apnea Syndromes Medicine anatomy_morphology Humans epigenetic mechanisms of disease Epigenetics Physical and Theoretical Chemistry Endothelial dysfunction Biology (General) Child Molecular Biology QD1-999 Spectroscopy obstructive sleep apnea DNA methylation business.industry histone modifications Organic Chemistry Sleep apnea General Medicine medicine.disease Obesity Computer Science Applications Obstructive sleep apnea Chemistry fetal programming Failure to thrive Chronic Disease medicine.symptom business Neurocognitive Protein Processing Post-Translational |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 9523, p 9523 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Pediatric obstructive sleep apnea has significant negative effects on health and behavior in childhood including depression, failure to thrive, neurocognitive impairment, and behavioral issues. It is strongly associated with an increased risk for chronic adult disease such as obesity and diabetes, accelerated atherosclerosis, and endothelial dysfunction. Accumulating evidence suggests that adult-onset non-communicable diseases may originate from early life through a process by which an insult applied at a critical developmental window causes long-term effects on the structure or function of an organism. In recent years, there has been increased interest in the role of epigenetic mechanisms in the pathogenesis of adult disease susceptibility. Epigenetic mechanisms that influence adaptive variability include histone modifications, non-coding RNAs, and DNA methylation. This review will highlight what is currently known about the phenotypic associations of epigenetic modifications in pediatric obstructive sleep apnea and will emphasize the importance of epigenetic changes as both modulators of chronic disease and potential therapeutic targets. |
| Databáze: | OpenAIRE |
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