Increased serum GHBP levels in obese pubertal children and adolescents: relationship to body composition, leptin and indicators of metabolic disturbances
| Autor: | Werner F. Blum, Ferdinand Pulzer, Martin Wabitsch, P Englaro, B Dehmel, Juergen Kratzsch, Eberhard Keller |
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| Rok vydání: | 1998 |
| Předmět: |
Leptin
Male medicine.medical_specialty Aging Waist Adolescent Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Overweight Body Mass Index chemistry.chemical_compound Waist–hip ratio Weight loss Internal medicine Weight Loss Medicine Humans Insulin Obesity Insulin-Like Growth Factor I Child Triglycerides Nutrition and Dietetics business.industry Cholesterol Body Weight Puberty Proteins medicine.disease Endocrinology chemistry Body Composition Linear Models Body Constitution Female medicine.symptom business Carrier Proteins Body mass index |
| Zdroj: | International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 21(12) |
| Popis: | OBJECTIVE: The serum concentration of the high-affinity growth hormone-binding protein (GHBP) is increased in obesity but the mechanisms are poorly understood. This study assessed the physiological mechanisms involved in the regulation of GHBP in adiposity. SUBJECTS AND MEASUREMENTS: We tested a number of obesity specific parameters for their association with GHBP. In this study, 199 normal or overweight children and adolescents (101 boys, 98 girls, aged (mean±s.d.): 13.7±2.3 y) underwent an anthropometric evaluation (circumference measurements and bioimpedance analysis) combined with blood withdrawal for the measurement of insulin-like growth factor-I (IGF-I), insulin, leptin and GHBP (by specific RIA), uric acid, triglycerides and cholesterol. RESULTS: By linear regression analysis GHBP correlated significantly (P |
| Databáze: | OpenAIRE |
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