Motile responses of isolated guinea pig vestibular hair cells
| Autor: | Jacques Lehouelleur, Jean Valat, Alain Sans, Corinne Griguer |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Vestibular system
integumentary system General Neuroscience Guinea Pigs Stimulation Anatomy Cuticular plate Kinocilium Biology Guinea pig medicine.anatomical_structure Cell Movement Vestibule Physical Stimulation Hair Cells Auditory otorhinolaryngologic diseases medicine Biophysics Potassium Animals Inner ear sense organs Vestibular Hair Cell |
| Zdroj: | Neuroscience letters. 127(2) |
| ISSN: | 0304-3940 |
| Popis: | Vestibular hair cells were isolated from the guinea pig vestibule by a micromechanical non-enzymatic procedure. Perfusion with 125 mM K+ solution induced irreversible slow shortening of the necks in 42.8% of the hair cells tested. Mechanical stimulation, creating a displacement of the hair bundle towards the kinocilium, induced either irreversible coiling or tilting of the neck of the cells, or reversible fast tilting of the cuticular plate (44.5% of tested cells). The response to the Ca2+ antagonist, Flunarizine, suggested that these movements were calcium-dependent. We propose several explanations of the physiological role of these mechanisms and discuss the possibility that fast tilting of the cuticular plate is a physiological movement involving the hair cells at the periphery of the vestibular receptors. The regulation of the vestibular message at the apex of type I hair cells is also considered. |
| Databáze: | OpenAIRE |
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