Microbes, intestinal inflammation and probiotics
| Autor: | Amod A Kale, Sriharsha Vajjala, Praveen Bere, Elias Gounaris, Mohammad W. Khan, Krishna Chaitanya Pakanati |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Innate immune system
Hepatology business.industry Probiotics Gastroenterology Inflammation Inflammatory Bowel Diseases medicine.disease Inflammatory bowel disease Epithelium Intestines medicine.anatomical_structure Immune system Intestinal inflammation Immunology medicine Animals Humans Probiotic bacteria Intestinal Mucosa medicine.symptom business Homeostasis |
| Zdroj: | Expert Review of Gastroenterology & Hepatology. 6:81-94 |
| ISSN: | 1747-4132 1747-4124 |
| Popis: | Inflammatory bowel disease (IBD) is known for causing disturbed homeostatic balance among the intestinal immune compartment, epithelium and microbiota. Owing to the emergence of IBD as a major cause of morbidity and mortality, great efforts have been put into understanding the sequence of intestinal inflammatory events. Intestinal macrophages and dendritic cells act in a synergistic fashion with intestinal epithelial cells and microbiota to initiate the triad that governs the intestinal immune responses (whether inflammatory or regulatory). In this review, we will discuss the interplay of intestinal epithelial cells, bacteria and the innate immune component. Moreover, whether or not genetic intervention of probiotic bacteria is a valid approach for attenuating/mitigating exaggerated inflammation and IBD will also be discussed. |
| Databáze: | OpenAIRE |
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