Oxidized HDL, Adipokines, and Endothelial Dysfunction: A Potential Biomarker Profile for Cardiovascular Risk in Women with Obesity
| Autor: | Lu Liu, Ellen Thompson, Kathleen O'Hanlon, Jeremy A. Weingarten, Stephen J. Peterson, Nader G. Abraham, Joseph I. Shapiro, Angelica Bialczak, Siddharth Bhesania, Shailendra P. Singh |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Population Medicine (miscellaneous) Adipokine 030209 endocrinology & metabolism Article 03 medical and health sciences 0302 clinical medicine Endocrinology Adipokines Risk Factors Internal medicine Diabetes mellitus medicine Animals Humans Obesity 030212 general & internal medicine Endothelial dysfunction education education.field_of_study Nutrition and Dietetics Adiponectin business.industry Leptin Endothelial Cells nutritional and metabolic diseases medicine.disease Cardiovascular Diseases cardiovascular system Female Lipoproteins HDL business Biomarkers Lipoprotein |
| Zdroj: | Obesity. 27:87-93 |
| ISSN: | 1930-739X 1930-7381 |
| DOI: | 10.1002/oby.22354 |
| Popis: | OBJECTIVE High BMI predicts adverse cardiovascular outcomes and positively correlates with increased levels of adipokines. The relationship among BMI, IL-6, TNFα, adiponectin, and oxidized high-density lipoprotein (Ox-HDL) with circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) has not been well studied. Elevated CEC levels have been described in both humans and mice with obesity and diabetes. Ox-HDL has been shown to be a potent driver of adipogenesis in vivo and in vitro. In this study, elevated BMI was examined in 2 groups of women studied in Brooklyn, New York, and Huntington, West Virginia, respectively. METHODS Twenty-six females with obesity and five lean controls without overt cardiovascular disease were enrolled, 13 from Huntington and 13 from Brooklyn. Cytokine levels, EPCs, and CECs were determined. RESULTS Females with obesity had elevated levels of leptin, IL-6, and Ox-HDL, increased CEC levels, and decreased EPC and adiponectin levels (all P |
| Databáze: | OpenAIRE |
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