Microbiota of newborn meconium is associated with maternal anxiety experienced during pregnancy
| Autor: | Yonglin Huang, Jianzhong Hu, Vivette Glover, Yasmin L. Hurd, Yoko Nomura, Inga Peter, Wei Zhang, Jenny Ly |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Meconium Offspring Gut–brain axis Physiology Anxiety Article Young Adult 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Enterococcaceae Developmental Neuroscience Pregnancy Developmental and Educational Psychology medicine Humans 0501 psychology and cognitive sciences Microbiome Depression (differential diagnoses) biology business.industry Microbiota 05 social sciences Infant Newborn biology.organism_classification medicine.disease Prenatal Exposure Delayed Effects Female medicine.symptom business 030217 neurology & neurosurgery 050104 developmental & child psychology Developmental Biology |
| Zdroj: | Dev Psychobiol |
| ISSN: | 0012-1630 |
| DOI: | 10.1002/dev.21837 |
| Popis: | Little is known about whether a mother’s psychological state during pregnancy influences her offspring’s microbiome. This study examined whether maternal anxiety, depression, and stress during pregnancy is associated with the diversity of meconium microbiome, the first internal discharge, in 75 newborns from an existing birth cohort study. The meconium microbiome was profiled using multi-barcode16S rRNA sequencing at V3-V4 hyper-variable region followed by taxonomic assignment to the green gene 16S references at 97% similarity and diversity analysis at the genus level. Results showed that the meconium contained diversified microbiota, and greater pregnancy-related anxiety was significantly associated with a less diverse meconium microbiota community (p-value=0.001). At the specific taxa level, greater pregnancy-related anxiety was correlated with a lower level of the Enterococcaceae family (p-value=2e-4, Spearman rho=−0.43). These findings support a significant role of prenatal maternal mood in the early life bacteria colonization of their offspring. |
| Databáze: | OpenAIRE |
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