Persistent vacuoles in leukocytes: Familial Jordans anomaly
| Autor: | Nukhet Tuzuner, M Taşyürekli, Lamia Ulukutlu, Fügen Çullu, R A Seger, O N Koç, O N Ulutin, L Sağlamer, F Oz |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Pathology medicine.medical_specialty Time Factors Muscle biopsy medicine.diagnostic_test Vacuole Granulocyte Biology Stain Microscopy Electron chemistry.chemical_compound medicine.anatomical_structure Vacuolization chemistry Cytoplasm Vacuoles Pediatrics Perinatology and Child Health Leukocytes medicine Humans Oil Red O Female Bone marrow Child |
| Zdroj: | Pediatrics International. 37:177-181 |
| ISSN: | 1328-8067 |
| DOI: | 10.1111/j.1442-200x.1995.tb03293.x |
| Popis: | Multiple persistent vacuoles were seen in the neutrophils, monocytes and eosinophils of a 9 year old boy and his 10 year old sister. The siblings were both asymptomatic. In the bone marrow, the cytoplasmic vacuoles were also present in the promyelocytes, myelocytes and metamyelocytes, but not in the myeloblasts and they tended to be single and large in immature cells. The cytoplasmic vacuoles did not stain with PAS, Sudan Black or Oil Red O; Sudan III positivity of the vacuoles was found only in a very small number of granulocytes. The vacuoles appeared as round and bright bodies with phase contrast microscopy. By electron microscopy, the vacuoles contained material of low electron density and had no surrounding membrane. Granulocyte functions were unimpaired. Muscle biopsy showed normal morphology. This anomalous vacuolization of the leukocytes is consistent with familial Jordans anomaly. |
| Databáze: | OpenAIRE |
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