Intracranial Germ Cell Tumors: A Comprehensive Update of the European Data
| Autor: | A. Pearson, M. Lo Curto, Michael Bamberg, J. R. Mann, L Cordero di Montezemolo, Giorgio Perilongo, H. G. Lenard, R. Schober, F. Fossati-Bellani, H. Jürgens, D. Schmidt, Y. Benoit, H. J. Kühl, U. Göbel, Gabriele Calaminus, C. Patte, M. C. Baranzelli |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Pathology Combination therapy medicine.medical_treatment Pharmacotherapy Drug Therapy Germany Humans Medicine Combined Modality Therapy Platinum Chemotherapy Germ cell neoplasm Suprasellar region business.industry CNS germ cell tumors - Combination therapy - Irradiation - Platinum Brain General Medicine Prognosis medicine.disease United Kingdom Radiation therapy Treatment Outcome Italy Pediatrics Perinatology and Child Health France Germinoma Neurology (clinical) Germ cell tumors Radiology business |
| Zdroj: | Neuropediatrics. 25:26-32 |
| ISSN: | 1439-1899 0174-304X |
| DOI: | 10.1055/s-2008-1071577 |
| Popis: | Intracranial germ cell tumors are rare tumor entities in childhood and adolescents. Extra- and intracranial germ cell tumors are identical in their histologic pattern and occur in preferential midline localizations such as the pineal and the suprasellar region. Germ cell neoplasms show increasing incidence rates over the last 30 years. The majority of intracranial germ cell neoplasms are germinomas. About 90% of the patients with pure germinomas can be salvaged by radiotherapy alone according to modern protocols. Non-germinomatous malignant CNS-germ cell tumors are considered to have a poor prognosis. In order to improve the survival of patients affected by these tumors different treatment approaches adding chemotherapy to conventional surgery and radiotherapy have been initiated by various study groups throughout the world. Due to the rarity of these neoplasms only a very limited number of patients has been enrolled in each study. In 1993 an international working group on these tumors was established by the International Society of Pediatric Oncology (SIOP). |
| Databáze: | OpenAIRE |
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