Role of growth factors in cutaneous wound healing: a review
| Autor: | C P Kiritsy, A B Lynch, S E Lynch |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Context (language use) Biology Bioinformatics Epithelium 03 medical and health sciences Paracrine signalling 0302 clinical medicine Skin Physiological Phenomena Skin Ulcer medicine Animals Humans Regeneration Growth Substances General Dentistry Skin Wound Healing Regeneration (biology) 030206 dentistry Clinical trial Chronic skin ulcers Disease Models Animal 030104 developmental biology Otorhinolaryngology Connective Tissue Cutaneous wound Soft tissue repair |
| Zdroj: | Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 4(5) |
| ISSN: | 1045-4411 |
| Popis: | The well-orchestrated, complex series of events resulting in the repair of cutaneous wounds are, at least in part, regulated by polypeptide growth factors. This review provides a detailed overview of the known functions, interactions, and mechanisms of action of growth factors in the context of the overall repair process in cutaneous wounds. An overview of the cellular and molecular events involved in soft tissue repair is initially presented, followed by a review of widely studied growth factors and a discussion of commonly utilized preclinical animal models. The article concludes with a summary of the preliminary results from human clinical trials evaluating the effects of growth factors in the healing of chronic skin ulcers. Throughout, the interactions among the growth factors in the wound-healing process are emphasized. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|