Novel neuroprotective strategies in ischemic retinal lesions
| Autor: | Krisztina Szabadfi, Krisztina Kovacs, Tamas Atlasz, Boglarka Racz, Peter Kiss, Laszlo Mester, Robert Gábriel, Andrea Tamas, Aliz Szabo, Norbert Babai, Dora Reglodi |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Retinal Artery Occlusion rat retina Ischemia BCCAO Review ischemia Pharmacology Biology PACAP Neuroprotection Catalysis urocortin 2 Inorganic Chemistry lcsh:Chemistry chemistry.chemical_compound Neurotrophic factors Internal medicine medicine Diazoxide Animals Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Urocortins Urocortin retinoprotection Organic Chemistry Retinal General Medicine medicine.disease Computer Science Applications Disease Models Animal Endocrinology Neuroprotective Agents chemistry lcsh:Biology (General) lcsh:QD1-999 Apoptosis PARP inhibitor Pituitary Adenylate Cyclase-Activating Polypeptide Benzimidazoles PARP-inhibitor medicine.drug |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 11, Iss 2, Pp 544-561 (2010) |
| ISSN: | 1422-0067 |
| Popis: | Retinal ischemia can be effectively modeled by permanent bilateral common carotid artery occlusion, which leads to chronic hypoperfusion-induced degeneration in the entire rat retina. The complex pathways leading to retinal cell death offer a complex approach of neuroprotective strategies. In the present review we summarize recent findings with different neuroprotective candidate molecules. We describe the protective effects of intravitreal treatment with: (i) urocortin 2; (ii) a mitochondrial ATP-sensitive K(+) channel opener, diazoxide; (iii) a neurotrophic factor, pituitary adenylate cyclase activating polypeptide; and (iv) a novel poly(ADP-ribose) polymerase inhibitor (HO3089). The retinoprotective effects are demonstrated with morphological description and effects on apoptotic pathways using molecular biological techniques. |
| Databáze: | OpenAIRE |
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