The activity of pomegranate extract standardized 40% ellagic acid during the healing process of incision wounds in albino rats (Rattus norvegicus)
| Autor: | Hardany Primarizky, Bambang Sektiari Lukiswanto, Wiwik Misaco Yuniarti |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Incision wound
Angiogenesis Veterinary medicine H&E stain Pharmacology 030226 pharmacology & pharmacy SF1-1100 03 medical and health sciences chemistry.chemical_compound pomegranate 0302 clinical medicine Fibrosis ellagic acid SF600-1100 Medicine Incised wound General Veterinary business.industry albino rats medicine.disease incision wound Staining Animal culture wound healing process chemistry 030220 oncology & carcinogenesis business Wound healing Ellagic acid |
| Zdroj: | Veterinary World, Vol 11, Iss 3, Pp 321-326 (2018) |
| ISSN: | 2231-0916 0972-8988 |
| Popis: | Aim: This research aimed to evaluate the effects of pomegranate extract standardized to 40% ellagic acid on the incised wound in albino rats. Materials and Methods: Fifty albino rats were divided into 10 treatment groups. The five groups were sacrificed on the 8th day, while the others were sacrificed on the 15th day. Two groups of albino rats with incised wound were not treated at all (P0), the other two groups of albino rats with incised wound were treated with Betadine® (P1) ointment, and the rest of the groups were treated with pomegranate extract standardized to 40% ellagic acid with a concentration of 2.5% (P2), 5% (P3), and 7.5% (P4). The treatments were carried out twice a day with an interval of 12 h for 7 and 14 days. At the end of the research, the skin tissue of those albino rats had been taken for histopathologic preparations before H and E staining was performed. Results: Collagen deposition, polymorphonuclear neutrophils (PMN) infiltration, angiogenesis, and fibrosis degree in Group P4 treated with 7.5% pomegranate extract standardized to 40% ellagic acid for 14 days were significantly different from those in Groups P0, P1, P2, and P3, especially in the case of PMN inflammation (p |
| Databáze: | OpenAIRE |
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