Immunoglobulin G in multiple sclerosis brain
| Autor: | Takeshi Hosokawa, Edward L. Hogan, John J. Marchalonis, Jeffery C. Hunt |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Pathology
medicine.medical_specialty Multiple Sclerosis Biochemistry Immunoglobulin G White matter Lesion Immunoenzyme Techniques Cellular and Molecular Neuroscience Antigen Pi medicine Humans biology Isoelectric focusing Chemistry Multiple sclerosis Brain Hydrogen-Ion Concentration medicine.disease In vitro medicine.anatomical_structure biology.protein Neurology (clinical) medicine.symptom Isoelectric Focusing |
| Zdroj: | Metabolic brain disease. 3(3) |
| ISSN: | 0885-7490 |
| Popis: | We extracted free and bound IgG from plaques and normal-appearing white matter of multiple sclerosis (MS) brains. By isoelectric focusing (IEF), three patterns of IgG distribution were seen: (A) a restricted high-pI distribution with a specific band at low pH, (B) a restricted high-pI pattern, and (C) a broad pI pattern similar to that of the unbound IgG extracted at neutral pH. In one MS brain, we compared the IEF pattern of plaque material with that of normal-appearing white matter (NAWM); the low-pH extract of plaque material (PM) had a restricted pattern at high pI. In another MS brain, a specific band of bound IgG was found. These data suggest that MS lesions expose an antigen(s) unique to MS. B cells consequently might be stimulated by a disease-related antigen(s) in the MS lesion. |
| Databáze: | OpenAIRE |
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