Role of nitric oxide in systemic hemodynamic responses to dobutamine, epinephrine, and amrinone
| Autor: | Mohamed R. Hemida, Jose M. Brum, Philip A. Khairallah, Fawzy G. Estafanous, Mostafa Shamloula, Badria El-Kasstawy |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Epinephrine Vasodilator Agents Hemodynamics Blood Pressure Vasodilation Pharmacology Arginine Nitric Oxide Nitric oxide Amrinone Rats Sprague-Dawley chemistry.chemical_compound Heart Rate Dobutamine Internal medicine medicine Animals Prospective Studies Cardiac Output Enzyme Inhibitors business.industry Stroke Volume Adrenergic beta-Agonists Rats NG-Nitroarginine Methyl Ester Anesthesiology and Pain Medicine Endocrinology medicine.anatomical_structure Mechanism of action chemistry Vascular resistance Vascular Resistance Nitric Oxide Synthase medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Cardiothoracic and Vascular Anesthesia. 9:627-633 |
| ISSN: | 1053-0770 |
| DOI: | 10.1016/s1053-0770(05)80221-6 |
| Popis: | Objective: This study was designed to investigate the extent to which the systemic vasodilator effects of dobutamine, epinephrine, and amrinone are modulated by the endothelium-derived relaxing factor, nitric oxide (NO). Design: This was a prospective study of low and high doses of the agonists before and after inhibition of NO synthesis. Setting: Experiments were performed in the basic research laboratories of the Center for Anesthesiology Research. Participants: Pentobarbital-anesthetized, intact Sprague-Dawley rats were studied in seven separate groups of eight rats each. Interventions: The systemic vasodilator responses to the agonists were assessed before and after the administration of the NO synthase inhibitor, NG-nitro-L-arginine methyl ester. Measurements and Main Results: Decreases in systemic vascular resistance in response to dobutamine and epinephrine were not observed after inhibition of NO synthesis, whereas the decrease in systemic vascular resistance in response to amrinone was still apparent. Conclusions: The results suggest that dobutamine and epinephrine produce systemic vasodilation through the release of NO, whereas amrinone produces vasodilation independent of NO release. |
| Databáze: | OpenAIRE |
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