Engineering biomaterials to prevent post-operative infection and fibrosis
Autor: | Laura M. Ensign, Ian Pitha, Aditya Josyula, Kunal S. Parikh |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Wound Healing Medical device Post operative infection business.industry Pharmaceutical Science Biomaterial Biocompatible Materials 02 engineering and technology 021001 nanoscience & nanotechnology medicine.disease 030226 pharmacology & pharmacy Fibrosis Article 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Drug delivery Quality of Life Medicine Humans 0210 nano-technology business Intensive care medicine |
Zdroj: | Drug Deliv Transl Res |
ISSN: | 2190-3948 |
Popis: | Implantable biomaterials are essential surgical devices, extending and improving the quality of life of millions of people globally. Advances in materials science, manufacturing, and in our understanding of the biological response to medical device implantation over several decades have resulted in improved safety and functionality of biomaterials. However, post-operative infection and immune responses remain significant challenges that interfere with biomaterial functionality and host healing processes. The objectives of this review is to provide an overview of the biology of post-operative infection and the physiological response to implanted biomaterials and to discuss emerging strategies utilizing local drug delivery and surface modification to improve the long-term safety and efficacy of biomaterials. |
Databáze: | OpenAIRE |
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