Molecular biology of colorectal cancer and clinical consequences for colorectal cancer syndromes
| Autor: | H.K. Schackert, O. N. Koufaki, Matthias Hahn |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Oncology
medicine.medical_specialty Mutation medicine.diagnostic_test business.industry Colorectal cancer Cancer Oncogenes Mouse model of colorectal and intestinal cancer medicine.disease_cause medicine.disease Penetrance Colorectal Neoplasms Hereditary Nonpolyposis Familial adenomatous polyposis Adenomatous Polyposis Coli Internal medicine medicine Humans Surgery Genes Tumor Suppressor Genetic Testing Carcinogenesis business Genetic testing |
| Zdroj: | Langenbeck's archives of surgery. 383(6) |
| ISSN: | 1435-2443 |
| Popis: | Because of the accomplishments in biotechnical research in the past few decades our knowledge about the molecular mechanisms of carcinogenesis has grown rapidly. Colorectal cancer has been one of the most intensively investigated tumor entities, and it seems to be well established that colorectal tumor growth is associated with an accumulation of acquired somatic mutational events in tumor suppressor genes and oncogenes. Recent progress in our understanding of the molecular basis of the most prevalent colorectal cancer syndromes, such as hereditary nonpolyposis colorectal cancer (HNPCC) and familial adenomatous polyposis (FAP), is reflected by modifications in diagnosis and therapy. Identification and characterization of the causative genes for these colorectal cancer syndromes have enabled precise presymptomatic detection of mutations in individuals who bear an a priori risk of about 50% of developing colorectal cancer. Genotype-phenotype correlations might further increase the clinical management of hereditary colorectal cancer. Even though developments in cancer research are restricted to the minority of individuals with hereditary cancer syndromes, growing knowledge about the effect of low penetrance variations in tumor suppressor genes may affect the diagnosis and therapy of sporadic colorectal cancer. |
| Databáze: | OpenAIRE |
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