Cellular pathways to beta-cell replacement
| Autor: | Tariq G. Fellous, Mairi Brittan, Malcolm R. Alison, Naomi Guppy |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Stem cell theory of aging Islets of Langerhans Transplantation Clinical uses of mesenchymal stem cells Epithelial Cells Biology Embryonic stem cell Cell biology Mesoderm Endocrinology medicine.anatomical_structure Diabetes Mellitus Type 1 Insulin-Secreting Cells Immunology Internal Medicine medicine Animals Humans Bone marrow Stem cell Progenitor cell Pancreas Adult stem cell Stem cell transplantation for articular cartilage repair Stem Cell Transplantation |
| Zdroj: | Diabetes/metabolism research and reviews. 23(2) |
| ISSN: | 1520-7552 |
| Popis: | In the twenty-first century, diabetic patients are likely to be one of the major beneficiaries from the advancement of regenerative medicine through cellular therapies. Though the existence of a specific self-renewing stem cell within the pancreas is still far from clear, a surprising variety of cells within the pancreas can differentiate towards a beta-cell phenotype: ductular cells, periductular mesenchymal cells and beta-cells themselves can all give rise to new beta-cells. Extra-pancreatic adult somatic stem cells, in particular, those originating from bone marrow may also be capable of differentiating to beta-cells, though equally well the beneficial effects of bone marrow cells may reside in their contribution to the damaged islet vasculature. Forced expression of the beta-cell-specific transcription factor Pdx1 in hepatocytes also holds promise as a therapeutic strategy to increase insulin levels in diabetic individuals. Embryonic stem (ES) cells are clearly another possible source for generating beta-cells, but ES cells are beyond the scope of this review, which focuses on adult stem and progenitor cells capable of producing beta-cells. Despite considerable endeavour, we still have much to learn in the field of pancreatic regeneration prior to any clinically applicable therapy based upon adult stem cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text