Stedim 6® and Clearflex®, two new multilayer materials for infusion containers. Comparative study of their compatibility with five drugs versus glass flasks and polyvinyl chloride bags
| Autor: | Janine Guerri, Charles B. Airaudo, Ould Mohamed Abdelmalik, Monique Verdier, André Gayte-Sorbier, Léopold Tchiakpé |
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| Rok vydání: | 1996 |
| Předmět: |
Chlorpromazine
Sodium Biomedical Engineering Biophysics chemistry.chemical_element Bioengineering Antidepressive Agents Tricyclic Biomaterials Structure-Activity Relationship Laboratory flask Crystallinity chemistry.chemical_compound Polyvinyl Chloride Clorazepate Dipotassium Infusion Pumps Diazepam Chromatography Borosilicate glass Chemistry Silicates Sorption Polyvinyl chloride Anti-Anxiety Agents Maprotiline Adsorption Glass Isotonic Solutions Clodronic Acid Polyethylenes Antipsychotic Agents |
| Zdroj: | Journal of Biomaterials Science, Polymer Edition. 7:199-206 |
| ISSN: | 1568-5624 0920-5063 |
| DOI: | 10.1163/156856295x00247 |
| Popis: | Stedim 6® and Clearflex®, two new polyethylene-lined materials for infusion bags, were studied for their compatibility with disodium clodronate, chlorpromazine and maprotiline hydrochlorides, diazepam, and clorazepate dipotassium salt, comparatively with borosilicate glass flasks and polyvinyl chloride bags. Diazepam, the only drug to exhibit a marked sorption in PVC bags (the loss reached 25% of the initial concentration after a contact duration of 72 h), showed lower sorption in Stedim 6® bags (loss about 11% under the same conditions) and none in Clearflex® bags. No significant difference was observed between the infusion solutions used as vehicles of the drugs (5% dextrose and 0.9% sodium chloride isotonic solutions). The results are discussed in terms of lipophilicity of the drugs and crystallinity of the polymers. |
| Databáze: | OpenAIRE |
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