Expression of MAGE-1 Gene by Esophageal Carcinomas
| Autor: | Uhi Tou, Teruo Kakegawa, Minako Sakaguchi, Hideaki Yamana, Hiromasa Fujita, Kyogo Itoh, Shigeki Shichijo, Yuji Toh |
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| Rok vydání: | 1995 |
| Předmět: |
endocrine system
Cancer Research Pathology medicine.medical_specialty Esophageal Neoplasms Molecular Sequence Data Specific immunotherapy Biology Gene product Esophagus Antigen Antigens Neoplasm Gene expression medicine Carcinoma Humans Cytotoxic T cell RNA Messenger neoplasms Neoplasm Staging Base Sequence Epithelioma Esophageal disease medicine.disease Neoplasm Proteins Gene Expression Regulation Neoplastic medicine.anatomical_structure Oncology Esophageal carcinoma Lymphatic Metastasis MAGE‐1 gene Cancer research Melanoma-Specific Antigens Rapid Communication |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 0910-5050 |
| Popis: | Expression of the MAGE genes encoding tumor-rejection antigens on HLA-A1 and -Cw1601 recognized by cytotoxic T lymphocytes was investigated in esophageal carcinomas at the mRNA level by the semiquantitative reverse transcription-polymerase chain reaction method. MAGE-1 and -2 genes, but not MAGE-3, -3/-6 and -4a/-4b genes, were expressed in substantial proportions of the primary esophageal carcinomas and their metastatic lymph nodes. The proportion of MAGE-positive samples in the primary esophageal carcinomas correlated with the T factor of the TNM classification (pT1 : 2 of 12 tumors, pT2 : 1 of 6, pT3 : 12 of 29, and pT4 : 7 of 18). These results have important implications for specific immunotherapy of esophageal carcinomas using MAGE-1 gene product. |
| Databáze: | OpenAIRE |
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