Phase diagram of a 4-component lipid mixture: DSPC/DOPC/POPC/chol
| Autor: | James D. Mastroianni, Tatyana M. Konyakhina, Frederick A. Heberle, Jing Wu, Gerald W. Feigenson |
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| Rok vydání: | 2013 |
| Předmět: |
Phase transition
Analytical chemistry Biophysics Quaternary phase diagram Thermodynamics 010402 general chemistry 01 natural sciences Biochemistry Phase Transition Article 03 medical and health sciences chemistry.chemical_compound Phosphatidylcholine Phase (matter) Fluorescence Resonance Energy Transfer Lipid bilayer phase behavior Lipid bilayer POPC 030304 developmental biology Phase diagram 0303 health sciences Component (thermodynamics) 4-Component lipid phase diagram Cell Biology 3. Good health 0104 chemical sciences Lipid raft Cholesterol chemistry Competing interaction Phosphatidylcholines Modulated phase 3-Dye method |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828(9):2204-2214 |
| ISSN: | 0005-2736 |
| DOI: | 10.1016/j.bbamem.2013.05.020 |
| Popis: | We report the first 4-component phase diagram for the lipid bilayer mixture, DSPC/DOPC/POPC/chol (distearoylphosphatidylcholine/dioleoylphosphatidylcholine/1-palmitoyl, 2-oleoylphosphatidylcholine/cholesterol). This phase diagram, which has macroscopic Ld + Lo phase domains, clearly shows that all phase boundaries determined for the 3-component mixture containing DOPC transition smoothly into the boundaries for the 3-component mixture containing POPC, which has nanoscopic phase domains of Ld + Lo. Our studies start from two published ternary phase diagrams, and show how these can be combined into a quaternary phase diagram by study of a few hundred samples of intermediate compositions. |
| Databáze: | OpenAIRE |
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