Fetal sex influences maternal fasting plasma glucose levels and basal β-cell function in pregnant women with normal glucose tolerance
| Autor: | Huijuan Lu, Lulu Geng, Congrong Wang, Pingyan Fang, Minfang Tao, Xinqian Geng, Yixie Shen, Ruihua Chen, Yinan Zhang, Weiping Jia |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Blood Glucose Male China medicine.medical_specialty Endocrinology Diabetes and Metabolism Mothers 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Carbohydrate metabolism Cohort Studies 03 medical and health sciences Fetus 0302 clinical medicine Endocrinology Pregnancy Insulin-Secreting Cells Internal medicine Diabetes mellitus Insulin Secretion Internal Medicine medicine Humans Insulin Glucose homeostasis Sex Characteristics business.industry Fasting General Medicine Odds ratio Glucose Tolerance Test medicine.disease Glucose Basal (medicine) Gestation Female Insulin Resistance business |
| Zdroj: | Acta Diabetologica. 54:1131-1138 |
| ISSN: | 1432-5233 0940-5429 |
| Popis: | Fetal sex has recently emerged as a new factor that is related to maternal glucose homeostasis during pregnancy. The present study aimed to investigate the effect of fetal sex on maternal glucose metabolism in women with normal glucose tolerance (NGT) during pregnancy in the Chinese population. A total of 877 pregnant women with NGT were recruited at 24–28 weeks of gestation and underwent a 75-g oral glucose tolerance test (OGTT). Pregnant women were divided into two groups according to fetal sex. Physical examinations and laboratory tests were performed. Pancreatic β-cell function and insulin sensitivity were evaluated using OGTT-derived indices. Compared with women bearing female fetuses, women who delivered male fetuses had higher fasting plasma glucose (FPG) concentrations [4.5 (4.2–4.8) vs. 4.4 (4.2–4.7) mmol/L, P |
| Databáze: | OpenAIRE |
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