Effects of therapy with diet and simvastatin on atherosclerosis in hypercholesterolemic patients
| Autor: | David H. G. Smith, Dirk P. Myburgh, Evan R. Soicher, Willem F. J. Steenkamp, Brian M. Friedman, Barlow Cw |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Simvastatin medicine.medical_specialty Hypercholesterolemia Coronary Artery Disease Coronary Angiography Gastroenterology chemistry.chemical_compound Internal medicine medicine Humans Pharmacology (medical) Lovastatin Coronary atherosclerosis Aged Pharmacology biology Cholesterol Vascular disease business.industry Anticholesteremic Agents General Medicine Middle Aged medicine.disease Combined Modality Therapy Hydroxymethylglutaryl-CoA reductase Regimen medicine.anatomical_structure Endocrinology chemistry HMG-CoA reductase biology.protein Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business Follow-Up Studies Artery medicine.drug |
| Zdroj: | Cardiovascular Drugs and Therapy. 4:1389-1394 |
| ISSN: | 1573-7241 0920-3206 |
| Popis: | We evaluated the effect of cholesterol reduction on atherosclerotic coronary artery lesions using diet and simvastatin, a potent HMG CoA reductase inhibitor. Fifteen subjects aged 28-69 years (mean 44), each of whom demonstrated significant (greater than 50%) narrowing of a coronary artery and a baseline cholesterol level greater than 278 mg/dl, were studied. Coronary arteriography was performed prior to and after 20 +/- 2.5 months of therapy. A 42% reduction in total serum cholesterol, a 52% reduction in LDL cholesterol, and an 87% increase in the HDL/LDL cholesterol ratio (p less than 0.01) were achieved. Pretreatment and posttreatment angiograms were reviewed by three experienced angiographers with temporal order masked. Improvement in the overall status of coronary atherosclerotic lesions was demonstrated in two patients (13%), while deterioration occurred in one patient (7%). No overall change was found in the remaining 12 patients (80%). We conclude that a cholesterol-lowering regimen using a nonatherogenic diet and simvastatin therapy may at least stabilize coronary atherosclerosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink