Interaction between warfarin and nonsteroidal anti-inflammatory drugs (NSAIDs) in rats
| Autor: | Michael A. Taylor, James T. Crowe, Pershottam P. Mathur, Lawrence F. Sancilio |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
Ketoprofen Time Factors medicine.drug_class Anti-Inflammatory Agents Diflunisal Pharmacology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound medicine Phenylbutazone Animals Drug Interactions General Pharmacology Toxicology and Pharmaceutics Prothrombin time Dose-Response Relationship Drug medicine.diagnostic_test Anticoagulant Warfarin Rats Inbred Strains Fasting General Medicine Ibuprofen Rats chemistry Prothrombin Time Amfenac medicine.drug |
| Zdroj: | Life Sciences. 36:1041-1050 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(85)90489-8 |
| Popis: | In fed rats, the following NSAIDs were administered orally 24 hr before or 18 hr after the intraperitoneal administration of 1.34 mg/kg warfarin: phenylbutazone, 150 mg/kg; diflunisal, 75 mg/kg; ibuprofen, 150 mg/kg; acetylsalicylic acid, 300 mg/kg; indomethacin, 8 mg/kg; tolmetin sodium, 50 mg/kg; ketoprofen, 8 mg/kg; and amfenac sodium, 8 mg/kg. The elevation of the 24-hr prothrombin time was indicative of the effect of the warfarin. Warfarin-treated fasted rats showed a significantly higher prothrombin time than warfarin-treated fed rats. Interaction with phenylbutazone and warfarin occurred in fed and not in fasted rats when administered 18 hr after administration of the warfarin. At the 24-hr pretreatment time, only phenylbutazone significantly reduced the elevated prothrombin time. With the exception of amfenac sodium, all the NSAIDs significantly enhanced the elevated prothrombin time when administered 18 hr after warfarin. Their decreasing order of activity in enhancing the elevated prothrombin time was phenylbutazone, diflunisal, acetylsalicylic acid, ibuprofen, indomethacin, tolmetin sodium, and ketoprofen. The results indicate that the rat is more sensitive than the human to the interaction between warfarin and NSAIDs. |
| Databáze: | OpenAIRE |
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