Administration of Thyroxin Once a Week*
| Autor: | Thomas Aceto, Christine B. Sekadde, W. R. Slaunwhite, Kathleen Murray |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Endocrinology Diabetes and Metabolism Clinical Biochemistry Absorption (skin) Biochemistry Endocrinology Pregnancy Internal medicine Elevated t4 medicine Humans Ingestion Euthyroid Child Normal range Triiodothyronine business.industry Biochemistry (medical) medicine.disease Thyroxine Weekly dose Female business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 39:759-764 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-39-4-759 |
| Popis: | L-Thyroxin was administered orally to 7 subjects (2 normal, 2 congenitally hypothyroid and 3 thyroidectomized subjects; all subjects were euthyroid at the time of the study and 1 was pregnant) in a single weekly dose; serum thyroxin (T4) and triiodothyronine (T3) concentrations were measured throughout the week. A dose of 1.4 mg/m2 leads to elevated T4 concentrations during the greater part of the week in all subjects, whereas at a dose of 1.1 mg/m2 T4 levels were elevated for only 2 days and remained in the high normal range for the rest of the week. T3 concentrations rose nearly as rapidly as T4 concentrations and tended to remain in the high euthyroid range throughout the week despite elevated T4 concentrations. The absorption peak occurred 2–4 hr after ingestion. |
| Databáze: | OpenAIRE |
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