Periorbital desmoplastic squamous cell carcinoma
| Autor: | Michelle T. Sun, Verona E. Botha, Rami H El-Khayat, Kent Chow, Stephen G J Ng, Paul Salmon, Dinesh Selva |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.medical_treatment Malignancy Metastasis 03 medical and health sciences 0302 clinical medicine Stroma medicine Humans Neoplasm 030223 otorhinolaryngology Aged Retrospective Studies Aged 80 and over business.industry Neck dissection Parotidectomy Middle Aged Mohs Surgery medicine.disease Desmoplasia stomatognathic diseases Ophthalmology medicine.anatomical_structure Cervical lymph nodes Carcinoma Squamous Cell 030221 ophthalmology & optometry Orbital Neoplasms Female Radiotherapy Adjuvant Neoplasm Recurrence Local medicine.symptom business Follow-Up Studies |
| Zdroj: | Orbit. 38:240-243 |
| ISSN: | 1744-5108 0167-6830 |
| DOI: | 10.1080/01676830.2018.1490438 |
| Popis: | Desmoplasia is the formation of a dense collagenous stroma around a neoplasm. It occurs in a variety of malignancies including squamous cell carcinoma (SCC). While desmoplasia is uncommonly seen in cutaneous SCC, it is an independent risk factor for recurrence and metastasis. We report a case series of desmoplastic SCC in the periorbital region. Seven cases were identified: the median age was 68, four were men. The mean follow-up was 48 months. Two patients (29%) had aggressive local recurrence: one required salvage surgery including orbital exenteration, parotidectomy, and neck dissection to excise involved parotid and cervical lymph nodes; the other required repeat excision and adjuvant radiotherapy. Desmoplastic SCC is an uncommon but highly aggressive subtype. In the periorbital region, due to the high risk of orbital invasion, it is potentially sight and life-threatening. |
| Databáze: | OpenAIRE |
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