A role for multiple estrogen receptors in immune regulation of common carp

Autor: E. Szwejser, Magdalena Chadzinska, B.M. Lidy Verburg-van Kemenade, Helmut Segner, Magdalena Maciuszek, Ayako Casanova-Nakayama
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Fish Proteins
medicine.medical_specialty
GPR30
Carps
medicine.drug_class
Neuroimmunomodulation
Immunology
Monocyte/macrophage
Estrogen receptor
Celbiologie en Immunologie
17 \beta-estradiol
Immune receptor
Estrogen receptors
Biology
Lymphocyte Activation
Receptors
G-Protein-Coupled
Immunomodulation
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Leukocytes
Animals
Estrogen Receptor beta
Immune response
Receptor
Estrogen receptor beta
Cells
Cultured
PELP-1
Estradiol
630 Agriculture
Estrogen Receptor alpha
17β-estradiol
Biological Evolution
Neurosecretory Systems
Cell biology
030104 developmental biology
Endocrinology
Cell Biology and Immunology
Estrogen
Carp
WIAS
Reactive Oxygen Species
Estrogen receptor alpha
GPER
030217 neurology & neurosurgery
Developmental Biology
Zdroj: Developmental and Comparative Immunology 66 (2017)
Developmental and Comparative Immunology, 66, 61-72
ISSN: 0145-305X
Popis: Estrogens are important for bi-directional neuroendocrine-immune interaction. They act via nuclear estrogen receptors (ERα and ERβ) and/or G-protein coupled receptor - GPR30. We found expression of ERα, ERβ and GPR30 in carp lymphoid tissues and head kidney monocytes/macrophages, neutrophils and lymphocytes. Interestingly, ERβ is also expressed in some head kidney lymphocytes but not in naive PBLs. Immune stimulation altered the cell type specific profile of expression of these receptors, which depends on both activation and maturation stage. This implies direct leukocyte responsiveness to estrogen stimulation and therefore in vitro effects of 17β-estradiol (E2) on reactive oxygen species (ROS) production in monocytes/macrophages were determined. Short-time incubation with E2 increased ROS production in PMA-stimulated cells. Results comply with mediation by GPR30, partially functioning via phosphoinositide 3-kinase activation. These results furthermore demonstrate that neuroendocrine-immune communication via estrogen receptors is evolutionary conserved.
Databáze: OpenAIRE
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