CD34 positive-microgranular variant of acute promyelocytic leukemia in a child
| Autor: | Ashwini Nargund, Geeta V Patil, E Venkataswamy, C P Raghuram |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Acute promyelocytic leukemia CD34 lcsh:QR1-502 Chromosomal translocation Antigens CD34 lcsh:Microbiology Pathology and Forensic Medicine Azurophilic granule Leukemia Promyelocytic Acute Differentiation therapy Bone Marrow hemic and lymphatic diseases medicine lcsh:Pathology Humans neoplasms Microscopy Blood Cells business.industry breakpoint cluster region Myeloid leukemia General Medicine PML-RARα medicine.disease Flow Cytometry Leukemia complete molecular remission Child Preschool Immunology Female business lcsh:RB1-214 |
| Zdroj: | Indian Journal of Pathology and Microbiology, Vol 55, Iss 4, Pp 574-577 (2012) |
| ISSN: | 0377-4929 |
| Popis: | Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. APL is rare in children (approximately 10% of childhood AML) and is characterized by a higher incidence of hyperleukocytosis, an increased incidence of microgranular morphology, the presence of balanced t(15;17)(q22;q11.2-12) translocation, and more frequent occurrence of the PML-RARα isoforms bcr 2 and bcr 3 compared to adults. The cytomorphology of microgranular variant blasts is obviously different from AML M3 blasts; these cells have a nongranular or hypogranular cytoplasm or contain fine dust-like cytoplasmic azurophil granules that may not be apparent by light microscopy. This case report emphasizes the importance of a high index of suspicion for the diagnosis of APL, the hypogranular variant in particular. They are responsive to differentiation therapy with all trans-retinoic acid and complete remission in seen in >80% cases. |
| Databáze: | OpenAIRE |
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