'Like parent, like child': Attention deficit hyperactivity disorder-like characteristics in parents of ADHD cases

Autor: Salvador Trejo, Yaira Chamorro, José A. Morales, María de Lourdes Ramírez-Dueñas, Esmeralda Matute, Adriana P. Mendizabal-Ruiz
Rok vydání: 2018
Předmět:
Adult
Male
Parents
Longitudinal study
Endophenotypes
Population
Neuropsychological Tests
Polymorphism
Single Nucleotide
050105 experimental psychology
03 medical and health sciences
Cellular and Molecular Neuroscience
Cognition
0302 clinical medicine
Gene Frequency
Continuous performance task
mental disorders
Reaction Time
Humans
Medicine
Attention deficit hyperactivity disorder
Attention
Genetic Predisposition to Disease
0501 psychology and cognitive sciences
Longitudinal Studies
Allele
education
Association (psychology)
Alleles
Genetics (clinical)
education.field_of_study
medicine.diagnostic_test
business.industry
Receptors
Dopamine D4
05 social sciences
Middle Aged
medicine.disease
Psychiatry and Mental health
Attention Deficit Disorder with Hyperactivity
Endophenotype
Female
Gene polymorphism
business
030217 neurology & neurosurgery
Clinical psychology
Zdroj: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 177:676-684
ISSN: 1552-4841
DOI: 10.1002/ajmg.b.32676
Popis: The objective of this study was to characterize an attention deficit hyperactivity disorder (ADHD) endophenotype in non-affected parents of adolescents with a history of ADHD, based on the relationship between performance on a sustained attention test (continuous performance task, or CPT) and polymorphisms of the DRD4 gene. In a sample of 25 non-affected parents of adolescents with ADHD history obtained from a longitudinal study of a nonclinical population, and 25 non-affected parents of adolescents with no ADHD history, four groups were evaluated with respect to the presence or absence of the long allele polymorphism of the DRD4 gene (i.e., over seven repeats). Comparisons of CPT performance among the four study groups included the number of commission errors, the number of omission errors, mean reaction time on correct responses (MRT), and reaction time (RT) variability (mean standard deviation of RT in each block [SDRT, as variability], and the sigma and tau components of the ex-Gaussian approach). The group of non-affected parents of adolescents with ADHD history and at least one long allele of the DRD4 gene showed greater RT variability (measured by SDRT), which is best explained by the greater frequency of abnormally slow responses (measured by tau). An association between the presence of the long allele of the DRD4 gene polymorphism and ADHD-like failure in CPT performance was evident in the non-affected parents of adolescents with ADHD in childhood. These findings suggest that certain traits of CPT performance could be considered an ADHD endophenotype.
Databáze: OpenAIRE
Externí odkaz: