Discovery of False Elite Controllers: HIV Antibody-Positive RNA-Negative Blood Donors Found To Be on Antiretroviral Therapy
| Autor: | Adam Jauregui, Genevieve Jacobs, Ronel Swanevelder, Nhlbi Recipient Epidemiology, Edward L. Murphy, Donor Evaluation Study-III, Karin van den Berg, Gary Maartens, Marion Vermeulen, Nareg Roubinian, Ute Jentsch, Lubbe Wiesner, Michael P. Busch, Wendy Sykes, Brian Custer |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty HIV antibody positive Human immunodeficiency virus (HIV) Blood Donors HIV Infections 030204 cardiovascular system & hematology medicine.disease_cause Antibodies Viral 03 medical and health sciences Major Articles and Brief Reports South Africa Young Adult 0302 clinical medicine Epidemiology medicine Immunology and Allergy Humans 030212 general & internal medicine Retrospective Studies biology business.industry HIV Middle Aged Antiretroviral therapy Virology Confidence interval Infectious Diseases Anti-Retroviral Agents biology.protein RNA Viral DONOR EVALUATION Female Antibody business Elite controllers |
| Zdroj: | J Infect Dis |
| Popis: | Background An increase in potential HIV elite controllers (EC) and anecdotal reports of antiretroviral therapy (ART) use among South African blood donors led us to verify EC status. Methods Stored plasma samples from potential EC were tested for ART drugs. Demographic and temporal associations were examined using multivariable logistic regression. Results Of 226 potential EC, 150 (66.4%) had detectable ART with increasing prevalence by year (OR = 7.57 for 2016 vs 2010, 95% confidence interval, 1.96–32.17). Discussion False presumptive EC status due to undisclosed ART represents a growing proportion of potential EC donors in South Africa coincident with the country’s ART rollout. |
| Databáze: | OpenAIRE |
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