Changes in body composition during and after adjuvant or neo-adjuvant chemotherapy in women with breast cancer stage I–IIIB compared with changes over a similar timeframe in women without cancer

Autor: Liesbeth Posthuma, J. Th C.M. de Kruif, M. van den Berg, Dieuwertje E. Kok, Y. de Vries, Dirkje W. Sommeijer, Renate M. Winkels, J.H.M. de Vries, Ellen Kampman, A Timmer-Bonte, H.W.M. van Laarhoven, Maartje Los, Marjolein Visser
Přispěvatelé: Epidemiology and Data Science, Human genetics, Medical oncology, Oncology, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and Quality of Life, Nutrition and Health, Methodology and Applied Biostatistics, APH - Health Behaviors & Chronic Diseases, APH - Aging & Later Life, APH - Societal Participation & Health
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Oncology
Adult
medicine.medical_specialty
Nutrition and Disease
medicine.medical_treatment
Breast Neoplasms
Body weight
Body composition
03 medical and health sciences
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]
0302 clinical medicine
Breast cancer
Absorptiometry
Photon
SDG 3 - Good Health and Well-being
Internal medicine
Voeding en Ziekte
medicine
Humans
Chemotherapy
030212 general & internal medicine
Stage (cooking)
Neo adjuvant chemotherapy
VLAG
Human Nutrition & Health
Neoplasm Staging
Global Nutrition
Wereldvoeding
business.industry
Other Research Radboud Institute for Health Sciences [Radboudumc 0]
Humane Voeding & Gezondheid
Body Weight
Cancer
Middle Aged
medicine.disease
Neoadjuvant Therapy
Chemotherapy
Adjuvant
030220 oncology & carcinogenesis
Lean body mass
Female
Original Article
business
Adjuvant
Zdroj: van den Berg, M M G A, Kok, D E, Visser, M, de Vries, J H M, de Kruif, J T C M, de Vries, Y, Posthuma, L, Sommeijer, D W, Timmer-Bonte, A, Los, M, van Laarhoven, H W M, Kampman, E & Winkels, R M 2020, ' Changes in body composition during and after adjuvant or neo-adjuvant chemotherapy in women with breast cancer stage I–IIIB compared with changes over a similar timeframe in women without cancer ', Supportive Care in Cancer, vol. 28, no. 4, pp. 1685-1693 . https://doi.org/10.1007/s00520-019-04951-6
Supportive Care in Cancer
Supportive Care in Cancer, 28(4), 1685-1693. Springer Verlag
Supportive Care in Cancer 28 (2020)
Supportive care in cancer, 28(4), 1685-1693. Springer Verlag
Supportive Care in Cancer, 28, 1685-1693
Supportive Care in Cancer, 28, 4, pp. 1685-1693
ISSN: 0941-4355
DOI: 10.1007/s00520-019-04951-6
Popis: Contains fulltext : 220748.pdf (Publisher’s version ) (Open Access) PURPOSE: Body weight and body composition may change during and after adjuvant or neo-adjuvant chemotherapy for breast cancer. However, most studies did not include a comparison group of women without cancer, thus could not assess whether observed changes differed from age-related fluctuations in body weight and body composition over time. We assessed changes in body composition during and after chemotherapy in breast cancer patients compared with age-matched women not diagnosed with cancer. METHODS: We recruited 181 patients with stage I-IIIb breast cancer and 180 women without cancer. In patients, we assessed body composition using a dual-energy X-ray scan before start of chemotherapy (T1), shortly after chemotherapy (T2), and 6 months after chemotherapy (T3); for the comparison group, the corresponding time points were recruitment (T1) and 6 (T2) and 12 (T3) months. RESULTS: Fifteen percent of patients and 8% of the comparison group gained at least 5% in body weight between T1 and T3. Among the comparison group, no statistically significant changes in body weight, or body composition were observed over time. Body weight of patients significantly increased from baseline (72.1 kg +/- 0.4 kg) to T2 (73.3 kg +/- 0.4 kg), but decreased to 73.0 kg +/- 0.4 kg after chemotherapy (T3). Lean mass of patients significantly increased from 43.1 kg +/- 0.5 kg at baseline to 44.0 kg +/- 0.5 kg at T2, but returned to 43.1 kg +/- 0.5 kg at T3. There were no differential changes in fat mass over time between patients and the comparison group. CONCLUSIONS: Changes in body weight and body composition during and after chemotherapy for early stage breast cancer were modest, and did not differ substantially from changes in body weight and body composition among women without cancer.
Databáze: OpenAIRE
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