Risk and coaggregation of major psychiatric disorders among first-degree relatives of patients with bipolar disorder: a nationwide population-based study
| Autor: | Tzeng Ji Chen, Wen Han Chang, Kei Lin Huang, Tung Ping Su, Tai Long Pan, Shih-Jen Tsai, Wei Chen Lin, Ju Wei Hsu, Cheng Ta Li, Ya Mei Bai, Chih Ming Cheng, Mu Hong Chen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Bipolar Disorder Adolescent Databases Factual Autism Spectrum Disorder Population Taiwan 03 medical and health sciences Young Adult 0302 clinical medicine mental disorders medicine Diseases in Twins Attention deficit hyperactivity disorder Humans Genetic Predisposition to Disease Bipolar disorder First-degree relatives Psychiatry education Applied Psychology Family Health education.field_of_study Depressive Disorder Major business.industry Mental Disorders Middle Aged medicine.disease Mental illness 030227 psychiatry Psychiatry and Mental health Schizophrenia Autism spectrum disorder Attention Deficit Disorder with Hyperactivity Major depressive disorder Female business 030217 neurology & neurosurgery |
| Zdroj: | Psychological medicine. 49(14) |
| ISSN: | 1469-8978 0033-2917 |
| Popis: | BackgroundBipolar disorder is a highly heritable mental illness that transmits intergeneratively. Previous studies supported that first-degree relatives (FDRs), such as parents, offspring, and siblings, of patients with bipolar disorder, had a higher risk of bipolar disorder. However, whether FDRs of bipolar patients have an increased risk of schizophrenia, major depressive disorder (MDD), autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD) remains unclear.MethodsAmong the entire population in Taiwan, 87 639 patients with bipolar disorder and 188 290 FDRs of patients with bipolar disorder were identified in our study. The relative risks (RRs) of major psychiatric disorders were assessed among FDRs of patients with bipolar disorder.ResultsFDRs of patients with bipolar disorder were more likely to have a higher risk of major psychiatric disorders, including bipolar disorder (RR 6.12, 95% confidence interval (CI) 5.95–6.30), MDD (RR 2.89, 95% CI 2.82–2.96), schizophrenia (RR 2.64, 95% CI 2.55–2.73), ADHD (RR 2.21, 95% CI 2.13–2.30), and ASD (RR 2.10, 95% CI 1.92–2.29), than the total population did. These increased risks for major psychiatric disorders were consistent across different familial kinships, such as parents, offspring, siblings, and twins. A dose-dependent relationship was also found between risk of each major psychiatric disorder and numbers of bipolar patients.ConclusionsOur study was the first study to support the familial coaggregation of bipolar disorder with other major psychiatric disorders, including schizophrenia, MDD, ADHD, and ASD, in a Taiwanese (non-Caucasian) population. Given the elevated risks of major psychiatric disorders, the public health government should pay more attention to the mental health of FDRs of patients with bipolar disorder. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|